Review



pbpk modelling tools pk-sim  (Bayer AG)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    Bayer AG pbpk modelling tools pk-sim
    <t>PBPK</t> modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table ).
    Pbpk Modelling Tools Pk Sim, supplied by Bayer AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pbpk+modeling+tools+pk-sim/pbpk+modeling+software+pk+sim/pmc05524914-292-13-7
    Average 90 stars, based on 1 article reviews
    pbpk modelling tools pk-sim - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage"

    Article Title: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

    Journal: Scientific Reports

    doi: 10.1038/s41598-017-04574-z

    PBPK modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table ).
    Figure Legend Snippet: PBPK modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table ).

    Techniques Used: Clinical Proteomics, Concentration Assay, Sampling, Expressing

    Physicochemical parameters used in the PBPK models.
    Figure Legend Snippet: Physicochemical parameters used in the PBPK models.

    Techniques Used: Molecular Weight

    Simulated plasma concentration profiles (lines) for healthy mice and the corresponding experimental data (points) (red: parent drug; blue: metabolite). PBPK simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).
    Figure Legend Snippet: Simulated plasma concentration profiles (lines) for healthy mice and the corresponding experimental data (points) (red: parent drug; blue: metabolite). PBPK simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).

    Techniques Used: Clinical Proteomics, Concentration Assay

    Simulated plasma concentration profiles (lines) for intoxicated mice and the corresponding experimental data (day one after CCl 4 administration, points) (red: parent drug; blue: metabolite), as well as the simulation of the healthy case (light red and light blue). The models for the damaged case were established by reducing the overall concentration of ADME-associated enzymes and transporters within the liver PBPK models. Simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).
    Figure Legend Snippet: Simulated plasma concentration profiles (lines) for intoxicated mice and the corresponding experimental data (day one after CCl 4 administration, points) (red: parent drug; blue: metabolite), as well as the simulation of the healthy case (light red and light blue). The models for the damaged case were established by reducing the overall concentration of ADME-associated enzymes and transporters within the liver PBPK models. Simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).

    Techniques Used: Clinical Proteomics, Concentration Assay

    Related Articles

    other:

    Article Title: In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
    Article Snippet: Lars Kuepfer is employed by Bayer AG, the company developing the PBPK modeling tools PK-Sim and MoBi.



    Similar Products

    pbpk modelling tools pk-sim  (Bayer AG)
    90
    Bayer AG pbpk modelling tools pk-sim
    <t>PBPK</t> modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table ).
    Pbpk Modelling Tools Pk Sim, supplied by Bayer AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pbpk+modeling+tools+pk-sim/pbpk+modeling+software+pk+sim/pmc05524914-292-13-7
    Average 90 stars, based on 1 article reviews
    pbpk modelling tools pk-sim - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier
    pbpk modeling tools pk-sim  (Bayer AG)
    90
    Bayer AG pbpk modeling tools pk-sim
    <t>PBPK</t> modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table ).
    Pbpk Modeling Tools Pk Sim, supplied by Bayer AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pbpk+modeling+tools+pk-sim/pbpk+modeling+software+pk+sim/pmc05316407-284-11-5
    Average 90 stars, based on 1 article reviews
    pbpk modeling tools pk-sim - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    PBPK modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table ).

    Journal: Scientific Reports

    Article Title: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

    doi: 10.1038/s41598-017-04574-z

    Figure Lengend Snippet: PBPK modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table ).

    Article Snippet: An.S., D.T. and L.K. are employees of Bayer AG, the company developing the PBPK modelling tools PK-Sim and MoBi.

    Techniques: Clinical Proteomics, Concentration Assay, Sampling, Expressing

    Physicochemical parameters used in the PBPK models.

    Journal: Scientific Reports

    Article Title: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

    doi: 10.1038/s41598-017-04574-z

    Figure Lengend Snippet: Physicochemical parameters used in the PBPK models.

    Article Snippet: An.S., D.T. and L.K. are employees of Bayer AG, the company developing the PBPK modelling tools PK-Sim and MoBi.

    Techniques: Molecular Weight

    Simulated plasma concentration profiles (lines) for healthy mice and the corresponding experimental data (points) (red: parent drug; blue: metabolite). PBPK simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).

    Journal: Scientific Reports

    Article Title: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

    doi: 10.1038/s41598-017-04574-z

    Figure Lengend Snippet: Simulated plasma concentration profiles (lines) for healthy mice and the corresponding experimental data (points) (red: parent drug; blue: metabolite). PBPK simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).

    Article Snippet: An.S., D.T. and L.K. are employees of Bayer AG, the company developing the PBPK modelling tools PK-Sim and MoBi.

    Techniques: Clinical Proteomics, Concentration Assay

    Simulated plasma concentration profiles (lines) for intoxicated mice and the corresponding experimental data (day one after CCl 4 administration, points) (red: parent drug; blue: metabolite), as well as the simulation of the healthy case (light red and light blue). The models for the damaged case were established by reducing the overall concentration of ADME-associated enzymes and transporters within the liver PBPK models. Simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).

    Journal: Scientific Reports

    Article Title: Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

    doi: 10.1038/s41598-017-04574-z

    Figure Lengend Snippet: Simulated plasma concentration profiles (lines) for intoxicated mice and the corresponding experimental data (day one after CCl 4 administration, points) (red: parent drug; blue: metabolite), as well as the simulation of the healthy case (light red and light blue). The models for the damaged case were established by reducing the overall concentration of ADME-associated enzymes and transporters within the liver PBPK models. Simulations are shown for caffeine and paraxanthine ( A ), midazolam and 1′-hydroxymidazolam ( B ), torsemide and hydroxytorsemide ( C ), codeine ( D ), talinolol ( E ), pravastatin ( F ).

    Article Snippet: An.S., D.T. and L.K. are employees of Bayer AG, the company developing the PBPK modelling tools PK-Sim and MoBi.

    Techniques: Clinical Proteomics, Concentration Assay